There are an increasing number of Spider-Man 3 spoilers on this site. An almost ridiculous amount, in fact (click around for joy). But I think, maybe, it is best if some things are kept under wraps.
Mainly just the things I can't substantiate, mind. I just don't really want to end up with egg on my face.
Chud have run a story that, I think, suggests one mother of a spoiler. They're telling the world that, basically, Uncle Ben was killed by Flint Marko, the Sandman, and not the carjacker crook we saw in the first film. Are they correct?
Do you really want to know? Sigh.
Of course, there's still a little room for argument about what this revelation might actually mean, so let me clear things up just a tad.
This scene is directly linked not only to the Spider-Man origin, but also that of Sandman. Both Peter and Flint reach turning points in their lives as a result of this moment. Obviously in very different respects, but the scene is dovetailed into the overall structure in a few neat ways, not just the most straightforward one.
And secondly, note that this represents the drawing together of first and third films in the series. There's actually a lot more of that going on than you might expect. You can quite safely say that Spider-Man 3 is very much the last in a trilogy, that it can be seen, if you want to, as bringing a certain, rather coherent chapter of the story to a pretty neat conclusion.
And, yes, "nothing in Peter's life will ever be the same again."